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KMID : 0380620090410050490
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Korean Journal of Food Science and Technology
2009 Volume.41 No. 5 p.490 ~ p.497
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Analysis of Amoxicillin, Ampicillin, Oxolinic Acid, and Flumequin in Foodsp
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Kim Hee-Yun
Choi Hee-Ju
Kim Yong-Hoon
Choi Sun-Hee
Cheong So-Young
Lee Hwa-Jung
Kim Jae-In
Choi Gye-Sun
Choi Jae-Chun
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Abstract
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The present study was performed to validate an analytical method for veterinary drugs, including amoxicillin, ampicillin, oxolinic acid and flumequin, in meat, fish, and their products as established in the 2007 Korea Food Code, and to monitor the respective drugs in 6 kinds of foods, namely beef, pork, flatfish, rockfish, freshwater eel and shrimp. Additionally, an HPLC-ESI-MS/MS method was developed for the qualification of these veterinary drugs. As a result of monitoring, these drugs were detected in 14 (3.6%) out of 393 samples. In particular, amoxicillin was detected in 9 flatfish samples, and oxolinic acid and flumequin were detected in 4 samples and 1 sample of freshwater eel, respectively. The detection levels of amoxicillin ranged from 0.009 to 0.078 mg/kg, in which 1 sample of flatfish contained more than the MRL (0.05 mg/kg). Flumequin detected in 1 sample of freshwater eel, was less than the MRL (0.5 mg/kg). Therefore, the majority of detected levels were less than the MRLs, with the exception of 2 samples showing amounts that were 1-2 times higher than the MRLs. The detected veterinary drugs were identified and confirmed by the HPLC-ESI-MS/MS method created in this study.
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KEYWORD
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amoxicillin, ampicillin, oxolinic acid, flumequin, mass spectrometry
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